{2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

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Chemical Name:{2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid
CAS No.:1437779-07-1
Molecular Formula:C₂₄H₂₉F₂N₃O₄
Molecular Weight:461.509
Hs Code.:

Synonyms:{2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

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Chemical Property of {2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

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Technology Process of {2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

There total 20 articles about {2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437779-06-0
methyl {2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetate

: 1437779-07-1
{2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

Guidance literature:: methyl {2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=4;

Reference yield:

: C₂₂H₂₆BrF₂N₃O₂

: 51656-70-3
(2-tert-butoxy-2-oxoethyl)zinc(II) bromide

: 1437779-07-1
{2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

Guidance literature:: C₂₂H₂₆BrF₂N₃O₂; (2-tert-butoxy-2-oxoethyl)zinc(II) bromide; With XPhos; at 65 ℃;

With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2017.01.091

Reference yield:

: 1437778-81-8
2-[(1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl]ethanol

: 1437779-07-1
{2,6-difluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

2.2: pH 4

With di-tert-butyl-diazodicarboxylate; water; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;