2-(4-hydroxyphenyl)-2-phenylcyclopentanone

Base Information

Chemical Name:2-(4-hydroxyphenyl)-2-phenylcyclopentanone
CAS No.:129315-79-3
Molecular Formula:C₁₇H₁₆O₂
Molecular Weight:252.313
Hs Code.:

Synonyms:2-(4-hydroxyphenyl)-2-phenylcyclopentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-hydroxyphenyl)-2-phenylcyclopentanone

Chemical Property:

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Technology Process of 2-(4-hydroxyphenyl)-2-phenylcyclopentanone

There total 8 articles about 2-(4-hydroxyphenyl)-2-phenylcyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 129315-78-2
2-(4-methoxyphenyl)-2-phenylcyclopentanone

: 129315-79-3
2-(4-hydroxyphenyl)-2-phenylcyclopentanone

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; for 16h; Heating;
DOI:10.1021/ja00174a036

Reference yield:

: 611-94-9
4-Methoxybenzophenone

: 129315-79-3
2-(4-hydroxyphenyl)-2-phenylcyclopentanone

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) THF, 55 deg C, 6 h, 2.) 55 deg C, 16 h

2: BF₃*Et₂O / benzene / 0.08 h

3: Jones' reagent, isopropyl alcohol / acetone / -10 °C

4: 1.) LDA / 1.) THF, hexane, 23 deg C, 1 h, 2.) 23 deg C, 16 h

5: thionyl chloride / CH₂Cl₂ / 16 h / 23 °C

6: AlCl₃ / CH₂Cl₂ / 0.5 h / 0 °C

7: 1.) L-Selectride, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, -78 deg C, 0.5 h, 2.) 0 deg C, 16 h

8: 89 percent / NaI, chlorotrimethylsilane / acetonitrile / 16 h / Heating

With sodium hydroxide; chloro-trimethyl-silane; aluminium trichloride; thionyl chloride; jones' reagent; boron trifluoride diethyl etherate; dihydrogen peroxide; L-Selectride; sodium hydride; isopropyl alcohol; sodium iodide; lithium diisopropyl amide; In dichloromethane; acetone; acetonitrile; benzene;
DOI:10.1021/ja00174a036

Reference yield:

: 16343-36-5
2-(4-methoxy-phenyl)-2-phenylacetaldehyde

: 129315-79-3
2-(4-hydroxyphenyl)-2-phenylcyclopentanone

Guidance literature:: Multi-step reaction with 6 steps

1: Jones' reagent, isopropyl alcohol / acetone / -10 °C

2: 1.) LDA / 1.) THF, hexane, 23 deg C, 1 h, 2.) 23 deg C, 16 h

3: thionyl chloride / CH₂Cl₂ / 16 h / 23 °C

4: AlCl₃ / CH₂Cl₂ / 0.5 h / 0 °C

5: 1.) L-Selectride, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, -78 deg C, 0.5 h, 2.) 0 deg C, 16 h

6: 89 percent / NaI, chlorotrimethylsilane / acetonitrile / 16 h / Heating

With sodium hydroxide; chloro-trimethyl-silane; aluminium trichloride; thionyl chloride; jones' reagent; dihydrogen peroxide; L-Selectride; isopropyl alcohol; sodium iodide; lithium diisopropyl amide; In dichloromethane; acetone; acetonitrile;
DOI:10.1021/ja00174a036