3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol

Base Information

Chemical Name:3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol
CAS No.:1583284-89-2
Molecular Formula:C₁₅H₁₃N₅OS
Molecular Weight:311.367
Hs Code.:

Synonyms:3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol

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Technology Process of 3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol

There total 4 articles about 3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1583284-78-9
4-chloro-6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidine

: 591-27-5
m-Hydroxyaniline

: 1583284-89-2
3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol

Guidance literature:: In ethanol; for 12h; Reflux; Inert atmosphere;
DOI:10.1021/co500004e

Reference yield:

: 1979-98-2
4,6-dihydroxy-2-methylmercaptopyrimidine

: 1583284-89-2
3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 1 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 12 h / Reflux; Inert atmosphere

2.1: triethylamine; hydrazine hydrate / 1,4-dioxane / 5 h / 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 - 100 °C / Cooling with ice; Inert atmosphere; Microwave irradiation

4.1: ethanol / 12 h / Reflux; Inert atmosphere

With di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1021/co500004e

Reference yield:

: 33097-11-9
4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde

: 1583284-89-2
3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrazine hydrate / 1,4-dioxane / 5 h / 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 - 100 °C / Cooling with ice; Inert atmosphere; Microwave irradiation

3: ethanol / 12 h / Reflux; Inert atmosphere

With di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1021/co500004e