Technology Process of 3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol
There total 4 articles about 3-(6-(methylthio)-1-(prop-2-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
ethanol;
for 12h;
Reflux;
Inert atmosphere;
DOI:10.1021/co500004e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate / 1 h / 20 °C / Cooling with ice; Inert atmosphere
1.2: 12 h / Reflux; Inert atmosphere
2.1: triethylamine; hydrazine hydrate / 1,4-dioxane / 5 h / 20 °C
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 - 100 °C / Cooling with ice; Inert atmosphere; Microwave irradiation
4.1: ethanol / 12 h / Reflux; Inert atmosphere
With
di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1021/co500004e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine; hydrazine hydrate / 1,4-dioxane / 5 h / 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 - 100 °C / Cooling with ice; Inert atmosphere; Microwave irradiation
3: ethanol / 12 h / Reflux; Inert atmosphere
With
di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1021/co500004e