2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester

Base Information

Chemical Name:2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester
CAS No.:175687-71-5
Molecular Formula:C₂₃H₃₁N₃O₆
Molecular Weight:445.516
Hs Code.:

Synonyms:2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester

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Chemical Property of 2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester

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Technology Process of 2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester

There total 7 articles about 2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methyl malonamic acid ethyl ester

: 175687-71-5
2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester

Guidance literature:: With triethylamine; Methanesulfonyl azide; In dichloromethane;
DOI:10.1016/0040-4020(95)01070-X

Reference yield:

: 40173-90-8
3,4-dimethoxyphenethyl bromide

: 175687-71-5
2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / K₂CO₃ / dimethylformamide / 2 h / Heating

2: 86 percent / cesium carbonate / dimethylformamide / 12 h / 90 °C

3: 1.) KOH / 1.) H₂O, 90 deg C, 12 h, 2.) xylene, reflux, 24 h

4: 1.) 1,1'-carbonyl diimidazole / 1.) CH₂Cl₂, 2 h, 2.) H₂O, from 0 deg C to RT, overnight

5: 95 percent / benzene / 3 h / Heating

6: 90 percent / Et₃N, mesyl azide / CH₂Cl₂

With potassium hydroxide; potassium carbonate; caesium carbonate; triethylamine; Methanesulfonyl azide; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0040-4020(95)01070-X

Reference yield:

: 1119-51-3
bromopentene

: 175687-71-5
2-diazo-N-<2-<2-(3,4-dimethoxyphenyl)ethyl>hept-6-enoyl>-N-methylmalonamic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / cesium carbonate / dimethylformamide / 12 h / 90 °C

2: 1.) KOH / 1.) H₂O, 90 deg C, 12 h, 2.) xylene, reflux, 24 h

3: 1.) 1,1'-carbonyl diimidazole / 1.) CH₂Cl₂, 2 h, 2.) H₂O, from 0 deg C to RT, overnight

4: 95 percent / benzene / 3 h / Heating

5: 90 percent / Et₃N, mesyl azide / CH₂Cl₂

With potassium hydroxide; caesium carbonate; triethylamine; Methanesulfonyl azide; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0040-4020(95)01070-X