(2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

Base Information

Chemical Name:(2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one
CAS No.:1256633-59-6
Molecular Formula:C₁₉H₂₅IO₅
Molecular Weight:460.309
Hs Code.:

Synonyms:(2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

Suppliers and Price of (2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

There total 1 articles about (2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1256633-53-0
C₁₄H₂₀O₄

: 168295-35-0
(2E,4E)-5-iodopenta-2,4-dienal

: 1256633-59-6
(2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

Guidance literature:: C₁₄H₂₀O₄; With triethylamine; (-)-diisopinocamphenylborane chloride; In diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

(2E,4E)-5-iodopenta-2,4-dienal; In diethyl ether; dichloromethane; at -78 - -20 ℃; for 16.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol102425n

Reference yield: 93.0%

: 1256633-59-6
(2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

: 123-38-6
propionaldehyde

: 1256633-60-9
C₂₂H₃₁IO₆

Guidance literature:: With samarium diiodide; In tetrahydrofuran; at -20 ℃; for 0.75h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol102425n

Reference yield:

: 1256633-59-6
(2S,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-9-iodo-2-methylnona-6,8-dien-3-one

: 1256633-72-3
(2S,3R,5R,6E,8E)-1-(3,4-dimethoxybenzyloxy)-9-iodo-2-methylnona-6,8-diene-3,5-diol

Guidance literature:: Multi-step reaction with 2 steps

1: samarium diiodide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere

2: water; potassium carbonate / methanol / 16 h / 20 °C

With samarium diiodide; water; potassium carbonate; In tetrahydrofuran; methanol; 1: Evans-Tishchenko reduction;
DOI:10.1021/ol102425n