N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide

Base Information

• Chemical Name: N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide
• CAS No.: 1319210-07-5
• Molecular Formula: C₂₄H₃₂N₂O₃
• Molecular Weight: 396.53
• Mol file: 1319210-07-5.mol

Synonyms:N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide

Chemical Property of N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide

There total 4 articles about N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1-(2-{[2-(diethylamino)ethyl]amino}phenyl)ethanone (96524-62-8) + p-propoxybenzoyl chloride (40782-58-9) → N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide (1319210-07-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm200370y

Reference yield:

2'-Fluoroacetophenone (445-27-2) → N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide (1319210-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 33 h / 100 °C

2: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm200370y

Reference yield:

4-propoxybenzoic acid (5438-19-7) → N-(2-acetylphenyl)-N-[2-(diethylamino)ethyl]-4-propoxybenzamide (1319210-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Reflux

2: triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm200370y

upstream raw materials:

1-(2-{[2-(diethylamino)ethyl]amino}phenyl)ethanone

p-propoxybenzoyl chloride

2'-Fluoroacetophenone

4-propoxybenzoic acid

Downstream raw materials:

1-[2-(diethylamino)ethyl]-2-(4-propoxyphenyl)quinolin-4(1H)-one