(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride

Base Information

• Chemical Name: (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride
• CAS No.: 72827-29-3
• Molecular Formula: C₁₆H₂₀N₄O₃*ClH
• Molecular Weight: 352.821
• Mol file: 72827-29-3.mol

Synonyms:(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride

Chemical Property of (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride

There total 1 articles about (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyloxycarbonyl-(S)-phenylalanyl-(S)-histidine methyl ester (16689-13-7) → (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride (72827-29-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; under 827.4 Torr;

DOI:10.1021/jm00127a041

Reference yield: 71.0%

Z-D-phenylglycine (17609-52-8) + (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride (72827-29-3) → Z-(D)-Phg-Phe-His-OMe

Guidance literature:

With N-ethylmorpholine;; (C₃H₇PO₂)3; In dichloromethane; N,N-dimethyl-formamide; for 25h; Ambient temperature;

Reference yield: 62.0%

(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester; hydrochloride (72827-29-3) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → Z-Gly-L-Phe-L-His-OMe (120609-53-2)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 5 ℃; for 65h;

DOI:10.1021/jm00127a041

upstream raw materials:

benzyloxycarbonyl-(S)-phenylalanyl-(S)-histidine methyl ester

Downstream raw materials:

Z-Gly-L-Phe-L-His-OMe

(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionic acid