N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide

Base Information

Chemical Name:N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide
CAS No.:1201662-34-1
Molecular Formula:C₄₄H₄₀Cl₂FN₃O₄S
Molecular Weight:796.79
Hs Code.:

Synonyms:N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide

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Chemical Property of N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide

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Technology Process of N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide

There total 7 articles about N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1201663-76-4
3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxy-N-(3-((isobutylamino)methyl)benzyl)benzenesulfonamide

: 17337-13-2
[1,1'-biphenyl]-2-yl-isocyanate

: 1201662-34-1
N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 0.25h;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1201662-34-1
N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 0.25 - 0.33 h / 0 °C

3.2: 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.1: methanol / 3.17 h / 20 °C / Reflux

5.2: 0.5 h / 0 °C

5.3: 1 h / 20 °C

6.1: tetrahydrofuran / 0.25 h / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; tetrakis catalyst; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1201662-34-1
N-(3-((3-(biphenyl-2-yl)-1-isobutylureido)methyl)benzyl)-3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 0.25 - 0.33 h / 0 °C

3.2: 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.1: methanol / 3.17 h / 20 °C / Reflux

5.2: 0.5 h / 0 °C

5.3: 1 h / 20 °C

6.1: tetrahydrofuran / 0.25 h / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; tetrakis catalyst; In tetrahydrofuran; methanol; dichloromethane; toluene;