Technology Process of tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate
There total 3 articles about tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(4-fluorophenyl)benzaldehyde; 1-(N-Boc-aminomethyl)-3-(aminomethyl)benzene;
In
methanol;
for 4h;
Inert atmosphere;
Reflux;
With
sodium tetrahydroborate;
In
methanol;
at 0 ℃;
for 1.33333 - 1.5h;
With
sodium hydrogencarbonate;
In
methanol; water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux
2.1: methanol / 4 h / Inert atmosphere; Reflux
2.2: 1.33 - 1.5 h / 0 °C
2.3: 1 h / 20 °C
With
potassium carbonate;
tetrakis catalyst;
In
methanol; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux
2.1: methanol / 4 h / Inert atmosphere; Reflux
2.2: 1.33 - 1.5 h / 0 °C
2.3: 1 h / 20 °C
With
potassium carbonate;
tetrakis catalyst;
In
methanol; toluene;
