tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate
CAS No.:1201663-73-1
Molecular Formula:C₂₆H₂₉FN₂O₂
Molecular Weight:420.527
Hs Code.:

Synonyms:tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

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Chemical Property of tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

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Technology Process of tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

There total 3 articles about tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 60992-98-5
4-(4-fluorophenyl)benzaldehyde

: 108467-99-8
1-(N-Boc-aminomethyl)-3-(aminomethyl)benzene

: 1201663-73-1
tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

Guidance literature:: 4-(4-fluorophenyl)benzaldehyde; 1-(N-Boc-aminomethyl)-3-(aminomethyl)benzene; In methanol; for 4h; Inert atmosphere; Reflux;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1.33333 - 1.5h;

With sodium hydrogencarbonate; In methanol; water; at 20 ℃; for 1h;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1201663-73-1
tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

With potassium carbonate; tetrakis catalyst; In methanol; toluene;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1201663-73-1
tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

With potassium carbonate; tetrakis catalyst; In methanol; toluene;