2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide

Base Information

• Chemical Name: 2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide
• CAS No.: 147241-10-9
• Molecular Formula: C₁₅H₂₁BrN₂O
• Molecular Weight: 325.249
• Mol file: 147241-10-9.mol

Synonyms:2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide

Chemical Property of 2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide

There total 1 articles about 2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

1-(2-methylaminoethyl)pyrrolidine (32776-22-0) + 3-Bromophenylacetic acid (1878-67-7) → 2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide (147241-10-9)

Guidance literature:

With dicyclohexyl-carbodiimide; 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, overnight;

DOI:10.1021/jm00057a006

Reference yield: 38.9%

2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide (147241-10-9) → [2-(3-Bromo-phenyl)-ethyl]-methyl-(2-pyrrolidin-1-yl-ethyl)-amine (710274-81-0)

Guidance literature:

With aluminium hydride; In tetrahydrofuran; for 0.0833333h; Ambient temperature;

DOI:10.1021/jm00057a006

Reference yield:

2-(3-Bromo-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide (147241-10-9) → N-<2-(3-iodophenyl)ethyl>-N-methyl-2-(1-pyrrolidinyl)ethylamine

Guidance literature:

Multi-step reaction with 2 steps

1: 38.9 percent / AlH₃ / tetrahydrofuran / 0.08 h / Ambient temperature

2: 1.) n-BuLi, 2.) Bu₃SnCl, 3.) I₂

With aluminium hydride; n-butyllithium; tributyltin chloride; iodine; In tetrahydrofuran;

DOI:10.1021/jm00057a006

upstream raw materials:

1-(2-methylaminoethyl)pyrrolidine

3-Bromophenylacetic acid

Downstream raw materials:

[2-(3-Bromo-phenyl)-ethyl]-methyl-(2-pyrrolidin-1-yl-ethyl)-amine