(S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester
CAS No.:175793-27-8
Molecular Formula:C₃₆H₅₀N₂O₄Si
Molecular Weight:602.889
Hs Code.:

Synonyms:(S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

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Technology Process of (S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

There total 6 articles about (S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2666-93-5
(S)-Leu-OMe

: 175793-37-0
(S)-3-Benzyl-4-[(R)-1-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-oxazolidine-2,5-dione

: 175793-27-8
(S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: In dichloromethane; for 15h;
DOI:10.1039/cc9960000161

Reference yield:

: Benzyl-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-methyl-but-(Z)-ylidene]-amine

: 175793-27-8
(S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NEt₃ / CH₂Cl₂ / 20 h

2: NH₄HCO₂ / Pd/C / propan-2-ol / 1 h / Heating

3: Me₂SO, P₂O₅ / 20 h

4: 81 percent / MCPBA / CH₂Cl₂ / 1 h / -40 °C

5: 95 percent / CH₂Cl₂ / 15 h

With ammonium formate; phosphorus pentoxide; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; isopropyl alcohol;
DOI:10.1039/cc9960000161

Reference yield:

: 178207-98-2
(3R,4R)-1-Benzyl-3-benzyloxy-4-[(R)-1-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-azetidin-2-one

: 175793-27-8
(S)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NH₄HCO₂ / Pd/C / propan-2-ol / 1 h / Heating

2: Me₂SO, P₂O₅ / 20 h

3: 81 percent / MCPBA / CH₂Cl₂ / 1 h / -40 °C

4: 95 percent / CH₂Cl₂ / 15 h

With ammonium formate; phosphorus pentoxide; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; isopropyl alcohol;
DOI:10.1039/cc9960000161