diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate

Base Information

• Chemical Name: diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate
• CAS No.: 1290593-38-2
• Molecular Formula: C₃₂H₂₈N₈O₈S₂
• Molecular Weight: 716.755
• Mol file: 1290593-38-2.mol

Synonyms:diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate

Chemical Property of diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate

There total 3 articles about diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-(4-aminophenyl)-4-benzoyl-5-phenyl-N-(5-sulphamoyl-1,3,4-thiadiazole-2-yl)-1H-pyrazole-3-carboxamide (1161947-50-7) + diethyl malonate (105-53-3) → diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate (1290593-38-2)

Guidance literature:

1-(4-aminophenyl)-4-benzoyl-5-phenyl-N-(5-sulphamoyl-1,3,4-thiadiazole-2-yl)-1H-pyrazole-3-carboxamide; With hydrogenchloride; sodium acetate; sodium nitrite; In water; at 0 - 5 ℃;

diethyl malonate; In ethanol; water;

DOI:10.3109/14756366.2010.491795

Reference yield:

C25H17N7O6S2 (1100715-17-0) → diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate (1290593-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodiumsulfide nonahydrate / water

2: hydrogenchloride; sodium acetate; sodium nitrite / water / 0 - 5 °C

With hydrogenchloride; sodiumsulfide nonahydrate; sodium acetate; sodium nitrite; In water;

DOI:10.3109/14756366.2010.491795

Reference yield:

4-benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (658081-76-6) → diethyl 2-(2-(4-(4-benzoyl-5-phenyl-3-((5-sulphamoyl-1,3,4-thiadiazol-2-yl)carbamoyl)-1H-pyrazol-1-yl)phenyl)hydrazono)malonate (1290593-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride

2: hydrogenchloride; sodiumsulfide nonahydrate / water

3: hydrogenchloride; sodium acetate; sodium nitrite / water / 0 - 5 °C

With hydrogenchloride; thionyl chloride; sodiumsulfide nonahydrate; sodium acetate; sodium nitrite; In water;

DOI:10.3109/14756366.2010.491795

upstream raw materials:

C₂₅H₁₇N₇O₆S₂

1-(4-aminophenyl)-4-benzoyl-5-phenyl-N-(5-sulphamoyl-1,3,4-thiadiazole-2-yl)-1H-pyrazole-3-carboxamide

diethyl malonate

4-benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid