Technology Process of 2-allyl-3-(4-benzyloxy-2-vinylphenyl)-2H-isoquinolin-1-one
There total 6 articles about 2-allyl-3-(4-benzyloxy-2-vinylphenyl)-2H-isoquinolin-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 1h;
2-(2-allyl-1-oxo-1,2-dihydroisoquinolin-3-yl)-5-benzyloxybenzaldehyde;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 1h;
DOI:10.1248/cpb.59.1169
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 6 h / -70 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux
4.1: dipyridinium dichromate / dichloromethane / 2 h / 20 °C
5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C
5.2: 1 h / 0 - 20 °C
With
hydrogenchloride; dipyridinium dichromate; n-butyllithium; water; potassium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
5.1: Wittig reaction / 5.2: Wittig reaction;
DOI:10.1248/cpb.59.1169
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dipyridinium dichromate / dichloromethane / 2 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C
2.2: 1 h / 0 - 20 °C
With
dipyridinium dichromate; n-butyllithium;
In
tetrahydrofuran; hexane; dichloromethane;
2.1: Wittig reaction / 2.2: Wittig reaction;
DOI:10.1248/cpb.59.1169
