1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline

Base Information

• Chemical Name: 1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline
• CAS No.: 676255-04-2
• Molecular Formula: C₂₃H₃₀N₂O₃S
• Molecular Weight: 414.569
• Mol file: 676255-04-2.mol

Synonyms:1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline

Chemical Property of 1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline

There total 10 articles about 1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline (769920-49-2) + benzenesulfonyl chloride (98-09-9) → 1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline (676255-04-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1039/c8sc02744g

Reference yield:

6-methoxy quinoline (5263-87-6) → 1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline (676255-04-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / H₂ / PtO₂ / methanol / 12 h / 3102.89 Torr

2: BBr₃ / CH₂Cl₂ / 4 h / -78 °C

3: NaOH / dioxane

4: Cs₂CO₃; KI / dimethylformamide / 90 °C

5: HCl / dioxane; CH₂Cl₂ / 20 °C

6: Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; boron tribromide; caesium carbonate; triethylamine; potassium iodide; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.04.004

Reference yield:

6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline dihydrochloride + benzenesulfonyl chloride (98-09-9) → 1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline (676255-04-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2006.04.004

upstream raw materials:

benzenesulfonyl chloride

6-Hydroxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester

6-(3-piperidin-1-yl-propoxy)-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester

6-methoxy quinoline

Downstream raw materials:

1-benzenesulfonyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline hydrochloride