2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide

Base Information

• Chemical Name: 2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide
• CAS No.: 172326-48-6
• Molecular Formula: C₂₁H₂₀ClN₃O₄
• Molecular Weight: 413.861
• Mol file: 172326-48-6.mol

Synonyms:2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide

Chemical Property of 2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide

There total 2 articles about 2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-Chloronicotinoyl chloride (49609-84-9) + 3-amino-4-<(benzyloxy)methyl>-2,6-dimethoxypyridine (172326-47-5) → 2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide (172326-48-6)

Guidance literature:

With N,N-diethyl-N-isopropylamine; In ethyl acetate; at 0 ℃;

DOI:10.1021/jm00024a011

Reference yield:

4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester (162709-27-5) → 2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide (172326-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / ethyl acetate

2: 47 percent / i-PrNEt₂ / ethyl acetate / 0 °C

With hydrogenchloride; N,N-diethyl-N-isopropylamine; In ethyl acetate;

DOI:10.1021/jm00024a011

Reference yield: 94.0%

ethylamine (75-04-7,85404-22-4) + 2-chloro-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide (172326-48-6) → 2-(ethylamino)-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide (1027299-36-0)

Guidance literature:

at 110 ℃;

DOI:10.1021/jm00024a011

upstream raw materials:

2-Chloronicotinoyl chloride

3-amino-4-<(benzyloxy)methyl>-2,6-dimethoxypyridine

4-<(Benzyloxy)methyl>-2,6-dimethoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

Downstream raw materials:

2-(ethylamino)-N-<4-<(benzyloxy)methyl>-2,6-dimethoxy-3-pyridinyl>-3-pyridinecarboxamide

Trifluoro-methanesulfonic acid 9-benzyloxymethyl-5-ethyl-11-oxo-10,11-dihydro-5H-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-7-yl ester