(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE

Base Information

Chemical Name:(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE
CAS No.:958329-41-4
Molecular Formula:C₂₄H₂₅ClN₂O₃S
Molecular Weight:456.993
Hs Code.:

Synonyms:(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE

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Chemical Property of (R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE

Chemical Property:

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Technology Process of (R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE

There total 6 articles about (R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: methyl 6-cyclopropyl-2-naphthoic acid

: 958332-58-6
N-{4-[(1R)-1-AMINOETHYL]-5-CHLORO-2-METHYLPHENYL}METHANESULFONAMIDE HYDROCHLORIDE

: 958329-41-4
(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 33626-98-1
methyl 6-bromo-2-naphthoate

: 958329-41-4
(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE

Guidance literature:: Multi-step reaction with 3 steps

1: tricyclohexylphosphine; palladium diacetate / toluene; water / 1 h / 100 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 2 h / 50 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 95-79-4
5-chloro-2-methyl-benzenamine

: 958329-41-4
(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-CYCLOPROPYL-2-NAPHTHAMIDE

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 20 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 24 h / 0 - 20 °C

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

4.1: sodium tetrahydroborate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere; Reflux

4.2: 1 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

With pyridine; hydrogenchloride; aluminum (III) chloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;