(Z)-Fluorotamoxifen

Base Information

Chemical Name:(Z)-Fluorotamoxifen
CAS No.:77588-48-8
Molecular Formula:C₂₆H₂₈FNO
Molecular Weight:389.513
Hs Code.:

Synonyms:(Z)-Fluorotamoxifen

Suppliers and Price of (Z)-Fluorotamoxifen

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-Fluorotamoxifen

Chemical Property:

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Technology Process of (Z)-Fluorotamoxifen

There total 11 articles about (Z)-Fluorotamoxifen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 97732-69-9
1-<4-(piperidinoazo)phenyl>-1-<4-<2-(N,N-dimethylamino)ethoxy>phenyl>-2-phenyl-1-butene

: 77588-48-8
(Z)-Fluorotamoxifen

: 73617-96-6
(E)-Fluorotamoxifen

Guidance literature:: With hydrogen fluoride; In benzene; Title compound not separated from byproducts; 1.) RT, 0.5 h, 2.) 50 deg C, 10 min;
DOI:10.1021/jm00148a022

Reference yield:

: 100-66-3
methoxybenzene

: 77588-48-8
(Z)-Fluorotamoxifen

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / AlCl₃ / CS₂ / 1 h / Ambient temperature

2: 1.) Mg / 2.) ether, 2.) ether, reflux, 4 h

3: 85 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

4: KOH / ethanol / 20 h / Heating

With potassium hydroxide; aluminium trichloride; boron tribromide; magnesium; In carbon disulfide; ethanol; dichloromethane;
DOI:10.1021/jm00148a022

Reference yield:

: 1151-94-6
4-methoxy-4'-nitrobenzophenone

: 77588-48-8
(Z)-Fluorotamoxifen

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / Na₂S₂O₄*H₂O / ethanol / Heating

2: 1.) conc. aq. HCl, NaNO₂ / 1.) H₂O, 20 min, 2.) H₂O, RT, 0.5 h

3: 37 percent / 40percent aq. HF / benzene / 1.) RT, 0.5 h, 2.) 50 deg C, 10 min

4: 1.) Mg / 2.) ether, 2.) ether, reflux, 4 h

5: 85 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

6: KOH / ethanol / 20 h / Heating

With hydrogenchloride; potassium hydroxide; sodium dithionite; hydrogen fluoride; boron tribromide; magnesium; sodium nitrite; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm00148a022