7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine

Base Information

• Chemical Name: 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine
• CAS No.: 1770840-43-1
• Molecular Formula: C₆H₅IN₄
• Molecular Weight: 260.037
• Hs Code.: 2933998090
• Mol file: 1770840-43-1.mol

Synonyms:7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine

Chemical Property of 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine

Chemical Property:

• Density: 2.43±0.1 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is an amine organic substance and can be used as an intermediate for APIs. 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine is a useful reagent in the synthesis of phosphoramidate GS-5734 prodrug for potential treatment of Ebola virus infections and in the preparation of Remdesivir as COVID-19 antiviral drug candidate.

Technology Process of 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine

There total 8 articles about 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrrolo[2,1-f][1,2,4]triazin-4-amine (159326-68-8) → 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine (1770840-43-1)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield: 81.0%

4-chloro-7-iodopyrrolo[1,2-f][1,2,4]triazine → 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine (1770840-43-1)

Guidance literature:

With ammonia; In tetrahydrofuran; methanol; at 20 - 55 ℃; for 18h;

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) → 7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine (1770840-43-1)

Guidance literature:

Multi-step reaction with 4 steps

1: aminosulfonic acid / water / 1.5 h / 0 °C

2: potassium hydroxide / water / 2 h / 0 - 10 °C

3: potassium carbonate / ethanol / 2 h / 80 °C

4: N-iodo-succinimide / N,N-dimethyl-formamide / 1 h / 0 °C

With N-iodo-succinimide; aminosulfonic acid; potassium carbonate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

pyrrolo[2,1-f][1,2,4]triazin-4-amine

2-pyrrole aldehyde

1H-pyrrole-2-carbonitrile

pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one

Downstream raw materials:

7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine