7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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Chemical Name:7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
CAS No.:158227-80-6
Molecular Formula:C₃₂H₃₂N₄O₄
Molecular Weight:536.63
Hs Code.:

Synonyms:7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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Chemical Property of 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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Technology Process of 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

There total 31 articles about 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 57378-89-9
2,3,5-tri-O-benzyl-D-ribofuranosyl bromide

: C₁₁H₁₃IN₄O₂

: 158227-80-6
7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Guidance literature:: C₁₁H₁₃IN₄O₂; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h; Inert atmosphere;

2,3,5-tri-O-benzyl-D-ribofuranosyl bromide; In diethyl ether; hexane; at -50 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In methanol; diethyl ether; hexane; water; Reagent/catalyst; Solvent; Inert atmosphere;

Reference yield: 82.0%

: 1355049-94-3
(3R,4R,5R)-2-(4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol

: 158227-80-6
7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 2h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tetlet.2011.11.055

Reference yield: 80.0%

: 57378-89-9
2,3,5-tri-O-benzyl-D-ribofuranosyl bromide

: 2328091-01-4
C₁₁H₁₃BrN₄O₂

: 158227-80-6
7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Guidance literature:: C₁₁H₁₃BrN₄O₂; With isopropylmagnesium chloride; In tetrahydrofuran; for 2h; Inert atmosphere;

2,3,5-tri-O-benzyl-D-ribofuranosyl bromide; In tetrahydrofuran; at -20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; methanol; water; Inert atmosphere;