Technology Process of 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
There total 31 articles about 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C11H13IN4O2;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
2,3,5-tri-O-benzyl-D-ribofuranosyl bromide;
In
diethyl ether; hexane;
at -50 ℃;
for 3h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; diethyl ether; hexane; water;
Reagent/catalyst;
Solvent;
Inert atmosphere;
- Guidance literature:
-
With
triethylsilane; boron trifluoride diethyl etherate;
In
dichloromethane;
at 0 ℃;
for 2h;
optical yield given as %de;
diastereoselective reaction;
DOI:10.1016/j.tetlet.2011.11.055
- Guidance literature:
-
C11H13BrN4O2;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
for 2h;
Inert atmosphere;
2,3,5-tri-O-benzyl-D-ribofuranosyl bromide;
In
tetrahydrofuran;
at -20 ℃;
for 3h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
Inert atmosphere;
