6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

Base Information

Chemical Name:6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile
CAS No.:305370-92-7
Molecular Formula:C₁₅H₉ClFN₅
Molecular Weight:313.721
Hs Code.:

Synonyms:6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

Suppliers and Price of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

There total 4 articles about 6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4-(3-chloro-4-fluoro-phenylamino)-6-nitro-[1.8]naphthyridine-3-carbonitrile hydrochloride

: 305370-92-7
6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

Guidance literature:: With iron; ammonium chloride; In methanol; for 1h; Heating;
DOI:10.1016/j.bmcl.2004.01.034

Reference yield:

: 42959-38-6
3-carboxy-2-chloro-5-nitro pyridine

: 305370-92-7
6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / SOCl₂ / 5 h / Heating

2: 70 percent / iPr₂NEt / CH₂Cl₂ / 16 h / Heating

3: 100 percent / aq. NH₃ / ethanol / 4 h / Heating

4: 70 percent / POCl₃ / 24 h / Heating

5: propan-2-ol / 3 h / Heating

6: 78 percent / aq. NH₄Cl; Fe / methanol / 1 h / Heating

With ammonium hydroxide; thionyl chloride; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2004.01.034

Reference yield:

: 305370-84-7
4-chloro-6-nitro-[1.8]naphthyridine-3-carbonitrile

: 305370-92-7
6-amino-4-(3-chloro-4-fluoro-phenylamino)-[1.8]naphthyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: propan-2-ol / 3 h / Heating

2: 78 percent / aq. NH₄Cl; Fe / methanol / 1 h / Heating

With iron; ammonium chloride; In methanol; isopropyl alcohol;
DOI:10.1016/j.bmcl.2004.01.034