305370-84-7 Usage
Uses
Used in Pharmaceutical Industry:
4-Chloro-6-nitro-1,8-naphthyridine-3-carbonitrile is used as an active pharmaceutical ingredient for its antibacterial and antifungal properties. Its ability to inhibit the growth of harmful microorganisms makes it a valuable compound in the development of new drugs to combat resistant infections.
Used in Synthesis of Heterocyclic Compounds:
This naphthyridine derivative is utilized as a key intermediate in the synthesis of various heterocyclic compounds. Its unique structure allows for the formation of diverse chemical entities with potential applications in different industries.
Used in Drug Development:
4-Chloro-6-nitro-1,8-naphthyridine-3-carbonitrile serves as a building block in the development of new drugs. Its chemical properties enable the creation of novel therapeutic agents with improved efficacy and selectivity.
Used as a Dye Intermediate:
In the dye industry, 4-chloro-6-nitro-1,8-naphthyridine-3-carbonitrile is used as an intermediate in the production of various dyes. Its chemical structure contributes to the color and stability of the resulting dyes.
Used in Organic Synthesis Processes:
4-chloro-6-nitro-1,8-naphthyridine-3-carbonitrile is employed in various organic synthesis processes due to its reactivity and functional groups. It can be used to synthesize a wide range of organic compounds for different applications, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 305370-84-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,5,3,7 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 305370-84:
(8*3)+(7*0)+(6*5)+(5*3)+(4*7)+(3*0)+(2*8)+(1*4)=117
117 % 10 = 7
So 305370-84-7 is a valid CAS Registry Number.
305370-84-7Relevant academic research and scientific papers
Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles
Wissner, Allan,Hamann, Philip R.,Nilakantan, Ramaswamy,Greenberger, Lee M.,Ye, Fei,Rapuano, Timothy A.,Loganzo, Frank
, p. 1411 - 1416 (2007/10/03)
The syntheses and EGFR kinase inhibitory activity of a series of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles are described. Both reversible and irreversible binding inhibitors were prepared. These series were compared with each other and with the corresponding 4-anilinoquinoline-3-carbonitriles. Compounds having a 1,7-naphthyridine core structure can retain high potency while those with a 1,8-naphthyridine core are significantly less active. These results are consistent with molecular modeling observations.
SUBSTITUTED-3-CYANO-[1.7],[1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES
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Page 47, (2010/02/06)
This invention provides compounds of formula (I) having structure (a) wherein A'' is a diavalent moiety selected from the group (a, b, c) which are useful as inhibitors of protein tyrosine kinase.
