7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine

Base Information

• Chemical Name: 7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine
• CAS No.: 1262193-84-9
• Molecular Formula: C₂₅H₂₃F₃N₆O₂
• Molecular Weight: 496.492
• Mol file: 1262193-84-9.mol

Synonyms:7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine

Chemical Property of 7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine

There total 4 articles about 7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine (1262193-83-8) + acetyl chloride (75-36-5) → 7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine (1262193-84-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

C12H6BrF3N4 (1262197-61-4) → 7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine (1262193-84-9)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 90 °C

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / isopropyl alcohol; methanol / 50 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; hydrogen; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol; 1: Suzuki-Miyaura Coupling;

Reference yield:

2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine (1262193-82-7) → 7-acetyl-5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine (1262193-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / isopropyl alcohol; methanol / 50 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; isopropyl alcohol;

upstream raw materials:

5,6,7,8-tetrahydro-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazine

acetyl chloride

4-methyl-1-[2-(methyloxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazole

C₁₂H₆BrF₃N₄