7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

Base Information

Chemical Name:7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide
CAS No.:1451009-84-9
Molecular Formula:C₂₁H₂₂BF₂N₃O
Molecular Weight:381.233
Hs Code.:

Synonyms:7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

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Chemical Property of 7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

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Technology Process of 7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

There total 10 articles about 7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1451009-83-8
7-(3-aminopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

: 98-88-4
benzoyl chloride

: 1451009-84-9
7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2013.05.037

Reference yield:

: 1451009-76-9
2-(3-azidopropyl)-1H-pyrrole

: 1451009-84-9
7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: polymer bound triphenylphosphine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 1 h / 0 °C / Inert atmosphere

With dmap; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2013.05.037

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1451009-84-9
7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzene / 18 h / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C

3.1: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: sodium azide / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

6.1: trichlorophosphate / dichloromethane / 0 - 20 °C / Inert atmosphere

6.2: 0 - 20 °C / Inert atmosphere

7.1: polymer bound triphenylphosphine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 1 h / 0 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; sodium azide; palladium on activated charcoal; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: |Wittig Olefination;
DOI:10.1016/j.tet.2013.05.037