2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane

Base Information

• Chemical Name: 2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane
• CAS No.: 71524-17-9
• Molecular Formula: C₂₀H₂₄N₂O₈
• Molecular Weight: 420.419
• Mol file: 71524-17-9.mol

Synonyms:2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane

Chemical Property of 2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane

There total 2 articles about 2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(8R,8'S)-dihydroguaiaretic acid (36469-60-0,121209-88-9,124649-78-1,66322-34-7) → 2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane (71524-17-9)

Guidance literature:

With nitric acid; acetic acid; In ethyl acetate;

DOI:10.1248/cpb.26.682 DOI:10.1248/cpb.27.1583

Reference yield:

Guaiaretsaeure → 2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane (71524-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / methanol

2: HNO₃, AcOH / ethyl acetate

With hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1248/cpb.27.1583

Reference yield:

2,3-dimethyl-1,4-di(3-methoxy-4-hydroxy-5-nitro-phenyl)butane (71524-17-9) → 5-[(2S,3R)-4-(3-hydroxy-4,5-dimethoxyphenyl)-2,3-dimethylbutyl]-2,3-dimethoxyphenol (66280-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone

2: (i) Sn, HCl, (ii) HNO₂, (iii) aq. H₂SO₄

With potassium carbonate; In acetone;

DOI:10.1248/cpb.26.682

upstream raw materials:

(8R,8'S)-dihydroguaiaretic acid

Downstream raw materials:

2,3-dimethyl-1,4-di(3,4-dimethoxy-5-nitro-phenyl)butane

5-[(2S,3R)-4-(3-hydroxy-4,5-dimethoxyphenyl)-2,3-dimethylbutyl]-2,3-dimethoxyphenol