2-Ethynyl-6-methylpyridin-3-amine

Base Information

• Chemical Name: 2-Ethynyl-6-methylpyridin-3-amine
• CAS No.: 757950-12-2
• Molecular Formula: C8H8 N2
• Molecular Weight: 132.165
• DSSTox Substance ID: DTXSID40594014
• Wikidata: Q82488702
• Mol file: 757950-12-2.mol

Synonyms:2-ETHYNYL-6-METHYLPYRIDIN-3-AMINE;757950-12-2;SCHEMBL3060800;DTXSID40594014;GPTCTFGMDQCTLB-UHFFFAOYSA-N;AKOS006307920;(2-ethynyl-6-methyl-pyridin-3-yl)amine;DB-203383

Chemical Property of 2-Ethynyl-6-methylpyridin-3-amine

Chemical Property:

• PSA: 38.91000
• LogP: 1.53470
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 132.068748264
• Heavy Atom Count: 10
• Complexity: 156

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C=C1)N)C#C

Technology Process of 2-Ethynyl-6-methylpyridin-3-amine

There total 1 articles about 2-Ethynyl-6-methylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(6-methyl-2-trimethylsilanylethynyl-pyridin-3-yl)amine (757950-11-1) → (2-ethynyl-6-methyl-pyridin-3-yl)amine (757950-12-2)

Guidance literature:

With sodium hydroxide; In methanol; water; at 0 - 20 ℃; for 4h;

Reference yield: 58.0%

(2-ethynyl-6-methyl-pyridin-3-yl)amine (757950-12-2) + 1,3-difluoro-5-iodobenzene (2265-91-0) → (2-(3,5-difluoro-phenylethynyl)-6-methyl-pyridin-3-yl)amine

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃; for 20h;

Reference yield: 21.0%

(2-ethynyl-6-methyl-pyridin-3-yl)amine (757950-12-2) + 3-iodobenzonitrile (69113-59-3) → 3-(3-amino-6-methyl-pyridin-2-ylethynyl)-benzonitrile

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃; for 48h;

upstream raw materials:

(6-methyl-2-trimethylsilanylethynyl-pyridin-3-yl)amine

Refernces