(2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

Base Information

Chemical Name:(2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane
CAS No.:189760-88-1
Molecular Formula:C₄₁H₆₄O₇Si
Molecular Weight:697.04
Hs Code.:

(2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

Synonyms:(2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

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Chemical Property of (2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

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Technology Process of (2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

There total 4 articles about (2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 131685-66-0
(2S,3S,4S,6R,8S,9S)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecan-4-ol

: 98-88-4
benzoyl chloride

: 189760-88-1
(2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 36h; Ambient temperature;
DOI:10.1021/jo00313a011

Reference yield:

: 131685-64-8
(2S,3R,6R,8S,9S)-3,9-dimethyl-8-<(R)-2-hydroxy-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecan-4-one

: 189760-88-1
(2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / imidazole / CH₂Cl₂ / 5 h / Ambient temperature

2: 55 percent / LiAlH₄ / tetrahydrofuran / 1 h / -78 °C

3: 95 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 36 h / Ambient temperature

With 1H-imidazole; dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00313a011

Reference yield:

: 131685-65-9
(2S,3R,6R,8S,9S)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecan-4-one

: 189760-88-1
(2S,3R,4S,6R,8S,9S)-4-(benzoyloxy)-3,9-dimethyl-8-<(R)-2-<(tert-butyldimethylsilyl)oxy>-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecane

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / LiAlH₄ / tetrahydrofuran / 1 h / -78 °C

2: 95 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 36 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00313a011