2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol

Base Information

Chemical Name:2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol
CAS No.:405274-76-2
Molecular Formula:C₁₉H₁₆Cl₂N₄O
Molecular Weight:387.268
Hs Code.:

Synonyms:2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol

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Chemical Property of 2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol

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Technology Process of 2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol

There total 7 articles about 2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 288-88-0
1,2,4-Triazole

: 405275-76-5
2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1,2-epoxypropane

: 405274-76-2
2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 90 ℃; for 24h;

Reference yield: 38.0%

: 120-72-9
indole

: 132507-95-0,81886-66-0
1,2-epoxy-2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)-propane

: 405274-76-2
2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol

Guidance literature:: indole; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h; Inert atmosphere;

1,2-epoxy-2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)-propane; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.3390/ph13080186

Reference yield:

: 58905-16-1
1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

: 405274-76-2
2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; dichloromethane / 72 h / Reflux

2.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

With sodium hydride; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide;
DOI:10.3390/ph13080186