5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

Base Information

Chemical Name:5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole
CAS No.:1422182-14-6
Molecular Formula:C₂₂H₂₆BrN₃O₃
Molecular Weight:460.371
Hs Code.:

Synonyms:5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

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Chemical Property of 5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

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Technology Process of 5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

There total 2 articles about 5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1422182-13-5
6-bromo-2-[N-methyl-N-(2-(tert-butyloxycarbonyl)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

: 74-88-4
methyl iodide

: 1422182-14-6
5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

: 1422182-15-7
6-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

Guidance literature:: With sodium hydroxide; In water; acetone; at 20 ℃; for 1h; Overall yield = 84 %; Overall yield = 900 mg; Cooling with ice;
DOI:10.1007/s10870-012-0358-x

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1422182-14-6
5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium metabisulfite / N,N-dimethyl-formamide / 120 °C

2: sodium hydroxide / water; acetone

With sodium metabisulfite; sodium hydroxide; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.2575

Reference yield:

: 1422182-14-6
5-bromo-1-methyl-2-[N-methyl-N-(2-(tert-butyloxycarbonyloxy)ethyl)-4-aminophenyl]-1H-benzo[d]imidazole

: C₂₄H₂₄BrN₃O₃S

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 4 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/jhet.2575