2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid

Base Information

Chemical Name:2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid
CAS No.:1352934-64-5
Molecular Formula:C₂₀H₁₅F₃N₂O₄
Molecular Weight:404.345
Hs Code.:

Synonyms:2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid

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Chemical Property of 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid

Chemical Property:

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Technology Process of 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid

There total 8 articles about 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352934-63-4
methyl 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetate

: 1352934-64-5
2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid

Guidance literature:: methyl 2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetate; With methanol; sodium hydroxide; for 4h; Cooling with ice;

With hydrogenchloride; In water;

Reference yield:

: 1352934-60-1
1-methoxy-7-(trifluoromethyl)isoquinoline

: 1352934-64-5
2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 18 h / 150 °C

2.1: potassium hydroxide / 72 h / 100 °C

3.1: ammonium acetate / 4 h / 160 °C

4.1: 4-methyl-morpholine / dichloromethane / 18 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

5.2: 18 h / 20 °C / Cooling with ice

6.1: sodium hydroxide; methanol / 4 h / Cooling with ice

With 4-methyl-morpholine; methanol; ammonium acetate; sodium hydride; potassium hydroxide; sodium hydroxide; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 215453-51-3
7-bromo-1-chloroisoquinoline

: 1352934-64-5
2-(((benzyloxy)carbonyl)(7-(trifluoromethyl)isoquinolin-1-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C

1.2: -78 - 20 °C

2.1: copper / N,N-dimethyl-formamide / 48 h / 80 °C

3.1: trichlorophosphate / 18 h / 150 °C

4.1: potassium hydroxide / 72 h / 100 °C

5.1: ammonium acetate / 4 h / 160 °C

6.1: 4-methyl-morpholine / dichloromethane / 18 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

7.2: 18 h / 20 °C / Cooling with ice

8.1: sodium hydroxide; methanol / 4 h / Cooling with ice

With 4-methyl-morpholine; methanol; n-butyllithium; ammonium acetate; copper; sodium hydride; potassium hydroxide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;