4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile

Base Information

Chemical Name:4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile
CAS No.:87489-67-6
Molecular Formula:C₂₅H₂₂N₄O₂S
Molecular Weight:442.541
Hs Code.:

Synonyms:4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile

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Chemical Property of 4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile

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Technology Process of 4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile

There total 4 articles about 4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 87489-68-7
4-((S)-2-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-nicotinonitrile

: 98-09-9
benzenesulfonyl chloride

: 87489-69-8
4-((S)-9-Benzenesulfonyl-2-methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-nicotinonitrile

: 87489-67-6
4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In benzene; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)88186-1

Reference yield:

: 61-49-4
[2-(1H-indol-3-yl)-ethyl]-methylamine

: 87489-67-6
4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / tetrahydrofuran; acetic acid / 4 h / Ambient temperature

2: 90 percent / ccH₂SO₄ / tetrahydrofuran / 24 h / Ambient temperature

3: hydrogenosulfate de N-tetrabutylammonium, 50percentNaOH / benzene / 0.5 h / Ambient temperature

With sodium hydroxide; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; acetic acid; benzene;
DOI:10.1016/S0040-4039(00)88186-1

Reference yield:

: 87496-11-5
Sodium; (Z)-2-(3-cyano-pyridin-4-yl)-ethenolate

: 87489-67-6
4-{(E)-2-[1-Benzenesulfonyl-3-(2-methylamino-ethyl)-1H-indol-2-yl]-vinyl}-nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / tetrahydrofuran; acetic acid / 4 h / Ambient temperature

2: 90 percent / ccH₂SO₄ / tetrahydrofuran / 24 h / Ambient temperature

3: hydrogenosulfate de N-tetrabutylammonium, 50percentNaOH / benzene / 0.5 h / Ambient temperature

With sodium hydroxide; sulfuric acid; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; acetic acid; benzene;
DOI:10.1016/S0040-4039(00)88186-1