methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

Base Information

Chemical Name:methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate
CAS No.:1295506-01-2
Molecular Formula:C₄₁H₆₁BrN₂O₆
Molecular Weight:757.849
Hs Code.:

Synonyms:methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

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Chemical Property of methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

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Technology Process of methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

There total 3 articles about methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.7%

: 1295505-82-6
methyl (2β,3β)-28-[(3-aminopropyl)amino]-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

: 1122-91-4
4-bromo-benzaldehyde

: 1295506-01-2
methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

Guidance literature:: methyl (2β,3β)-28-[(3-aminopropyl)amino]-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate; 4-bromo-benzaldehyde; In methanol; at 20 ℃; for 4h; Inert atmosphere;

With sodium cyanoborohydride; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1002/cbdv.201000339

Reference yield:

: 1802-12-6
phytolaccagenine

: 1295506-01-2
methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 4 h / 60 °C / Inert atmosphere

2.1: methanol / 4 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201000339

Reference yield:

: 65497-07-6
3-O-(β-D-glucopyranosyl-(1->4)-β-D-xylopyranosyl)-phytolaccagenin

: 1295506-01-2
methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / methanol / 20 h / 4 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 4 h / 60 °C / Inert atmosphere

3.1: methanol / 4 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201000339