1802-12-6

Usage

Uses

Used in Pharmaceutical Applications:
Phytolaccagenin is used as a bioactive compound for its antiproliferative properties in humans. It has the potential to be developed into a pharmaceutical agent targeting the inhibition of cell proliferation, which could be beneficial in treating various diseases and conditions related to uncontrolled cell growth.
Used in Cancer Research:
Phytolaccagenin is used as a research tool for studying the mechanisms behind its antiproliferative activities. This can help in understanding its potential role in cancer treatment and prevention, as well as in the development of new therapeutic strategies against cancer.
Used in Traditional Medicine:
Phytolaccagenin is used in traditional medicine practices, where the Phytolacca plant has been utilized for its various health benefits. The compound may be incorporated into herbal remedies and supplements for promoting overall health and well-being.
Used in Drug Delivery Systems:
Similar to gallotannin, Phytolaccagenin could be used in the development of novel drug delivery systems to enhance its applications and efficacy against specific health conditions. This may involve the use of organic and metallic nanoparticles as carriers for improved delivery, bioavailability, and therapeutic outcomes.

InChI:InChI=1/C31H48O7/c1-26(25(37)38-6)11-13-31(24(35)36)14-12-29(4)18(19(31)15-26)7-8-22-27(2)16-20(33)23(34)28(3,17-32)21(27)9-10-30(22,29)5/h7,19-23,32-34H,8-17H2,1-6H3,(H,35,36)

Upstream product

• 508-02-1 Oleanolic acid 
• 65497-07-6 3-O-(β-D-glucopyranosyl-(1->4)-β-D-xylopyranosyl)-phytolaccagenin 
• 65497-07-6 EsA 

Downstream Products

• 1295505-83-7 methyl (2β,3β)-28-{[3-(benzoylamino)propyl]amino}-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate 
• 1295505-92-8 methyl (2β,3β)-2,3,23-trihydroxy-28-({3-[(4-methylbenzoyl)amino]propyl}amino)-28-oxoolean-12-en-30-oate 
• 1295505-93-9 methyl (2β,3β)-2,3,23-trihydroxy-28-({3-[ (4-hydroxybenzoyl)amino]propyl}amino)-28-oxoolean-12-en-30-oate 
• 1295505-94-0 methyl (2β,3β)-2,3,23-trihydroxy-28-({3-[(4-methoxybenzoyl)amino]propyl}amino)-28-oxoolean-12-en-30-oate 
• 1295505-95-1 methyl (2β,3β)-28-[(3-{[4-(dimethylamino)benzoyl]amino}propyl)amino]-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate 
• 1295505-96-2 methyl (2β,3β)-2,3,23-trihydroxy-28-oxo-28-({3-[(3-phenylpropanoyl)amino]propyl}amino)olean-12-en-30-oate 
• 1295505-84-8 methyl (2β,3β)-2,3,23-trihydroxy-28-oxo-28-{[3-(L-phenylalanylamino)propyl]amino}olean-12-en-30-oate 
• 1295505-99-5 L-phenylalanyl-N-(3-{[(2β,3β)-2,3,23-trihydroxy-30-methoxy-28,30-dioxoolean-12-en-28-yl]amino}propyl)-L-phenylalaninamide 
• 1295505-85-9 methyl (2β,3β)-28-{[3-(benzylamino)propyl]amino}-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate 
• 1295506-00-1 methyl (2β,3β)-2,3,23-trihydroxy-28-({3-[(4-methylbenzyl)amino]propyl}amino)-28-oxoolean-12-en-30-oate 
• 1295506-01-2 methyl (2β,3β)-28-({3-[(4-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate 
• 1295506-02-3 methyl (2β,3β)-28-({3-[(3-bromobenzyl)amino]propyl}amino)-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate 
• 1295506-03-4 methyl (2β,3β)-2,3,23-trihydroxy-28-({3-[(3-hydroxybenzyl)amino]propyl}amino)-28-oxoolean-12-en-30-oate 
• 1345011-84-8 methyl (2β,3β)-28-[(3-{[4-(dimethylamino)benzyl]amino}propyl)amino]-2,3,23-trihydroxy-28-oxoolean-12-en-30-oate 

Relevant academic research and scientific papers

Synthesis of novel derivatives of esculentoside A and its aglycone phytolaccagenin, and evaluation of their haemolytic activity and inhibition of lipopolysaccharide-induced nitric oxide production

A series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)-induced NO production, haemolytic activity, and cell viability was evaluated. Structure-ac

New approaches to the structural modification of olean-type pentacylic triterpenes via microbial oxidation and glycosylation

Microbial transformation of 4 olean-type pentacyclic triterpenes (OPTs), 3-oxo oleanolic acid (1), 3-acetyl oleanolic acid (2), oleanolic acid (3), and esculentoside A (4) was studied. After the screening of 12 strains of microbes, preparative biotransformation by two strains of Streptomyces griseus ATCC 13273 and Aspergillus ochraceus CICC 40330 resulted in the isolation of 10 metabolites. The microbial catalyzed high efficient regio-selective methyl oxidation and glycosylation were discovered, which could be provided as an alternative method to expand the structural diversity of OPTs. All the structures of the metabolites were elucidated unambiguously by ESI-MS, 1H NMR, 13C NMR, and 2D-NMR spectroscopy.

METHODS AND COMPOSITIONS RELATED TO AGLYCOSIDIC ESCULENTOSIDE A

Disclosed are compositions related to water soluble selective COX-2 inhibitors and methods of using the inhibitors (including h-EsA and derivatives thereof.)