2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one

Base Information

Chemical Name:2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one
CAS No.:411208-92-9
Molecular Formula:C₂₉H₂₇BrN₂O₃S
Molecular Weight:563.515
Hs Code.:

2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1<i>H</i>-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1<i>H</i>-pyridin-4-one

Synonyms:2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one

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Chemical Property of 2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one

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Technology Process of 2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one

There total 6 articles about 2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 411208-92-9
2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: MgSO₄ / toluene / 12 h / Heating

2: ZnCl₂ / CH₂Cl₂ / 2 h / -20 °C

3: TBAF

4: CBr₄; PPh₃

With carbon tetrabromide; tetrabutyl ammonium fluoride; magnesium sulfate; triphenylphosphine; zinc(II) chloride; In dichloromethane; toluene; 2: aza-Diels-Alder reaction;
DOI:10.1016/S0040-4039(01)02070-6

Reference yield:

: 140920-82-7
1-(O-tert-butyldimethylsilyl)-2-<3-(1-phenylsulfonyl)indolyl>ethanol

: 411208-92-9
2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 63 percent / tetrahydrofuran / -78 °C

2.1: MgSO₄ / toluene / 12 h / Heating

3.1: ZnCl₂ / CH₂Cl₂ / 2 h / -20 °C

4.1: TBAF

5.1: CBr₄; PPh₃

With carbon tetrabromide; tetrabutyl ammonium fluoride; magnesium sulfate; triphenylphosphine; zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; toluene; 3.1: aza-Diels-Alder reaction;
DOI:10.1016/S0040-4039(01)02070-6

Reference yield:

: 411208-90-7
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

: 411208-92-9
2-[1-benzenesulfonyl-3-(2-bromo-ethyl)-1H-indol-2-yl]-1-(1-phenyl-ethyl)-2,3-dihydro-1H-pyridin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: MgSO₄ / toluene / 12 h / Heating

2: ZnCl₂ / CH₂Cl₂ / 2 h / -20 °C

3: TBAF

4: CBr₄; PPh₃

With carbon tetrabromide; tetrabutyl ammonium fluoride; magnesium sulfate; triphenylphosphine; zinc(II) chloride; In dichloromethane; toluene; 2: aza-Diels-Alder reaction;
DOI:10.1016/S0040-4039(01)02070-6