3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

Base Information

Chemical Name:3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde
CAS No.:411208-90-7
Molecular Formula:C₂₃H₂₉NO₄SSi
Molecular Weight:443.639
Hs Code.:

Synonyms:3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

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Chemical Property of 3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

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Technology Process of 3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

There total 8 articles about 3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 140920-82-7
1-(O-tert-butyldimethylsilyl)-2-<3-(1-phenylsulfonyl)indolyl>ethanol

: 411208-90-7
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

Guidance literature:: 1-(O-tert-butyldimethylsilyl)-2-<3-(1-phenylsulfonyl)indolyl>ethanol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Darkness;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 25 ℃; Darkness;
DOI:10.1016/j.tetasy.2012.10.015

Reference yield:

: 1268479-64-6
C₁₇H₁₅NO₄S

: 18162-48-6
tert-butyldimethylsilyl chloride

: 411208-90-7
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja1116974

Reference yield:

: 1268479-44-2
C₁₈H₁₇NO₄S

: 411208-90-7
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: tin(IV) chloride / dichloromethane / 1 h / -78 - -10 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

3: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; water; tin(IV) chloride; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja1116974