4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole

Base Information

Chemical Name:4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole
CAS No.:115802-62-5
Molecular Formula:C₂₁H₂₅NO₄
Molecular Weight:355.434
Hs Code.:

Synonyms:4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole

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Chemical Property of 4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole

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Technology Process of 4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole

There total 1 articles about 4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 2746-25-0
p-Methoxybenzyl bromide

: 57193-17-6
4,4-dimethyl-2-(3,4-dimethoxyphenyl)-2-oxazoline

: 115802-62-5
4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole

Guidance literature:: With n-butyllithium; In diethyl ether; at -5 ℃; for 0.5h;

Reference yield: 22.0%

: 115802-62-5
4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole

: 115802-58-9
3,4-dimethoxy-2-(4'-methoxybenzyl)benzoic acid

Guidance literature:: With hydrogenchloride; at 130 ℃; for 12h;

Reference yield:

: 115802-62-5
4,5-dihydro-2-<3,4-dimethoxy-2-(4'-methoxybenzyl)phenyl>-4,4-dimethyloxazole

: 115888-85-2
(+/-)-latifine dimethyl ether

Guidance literature:: Multi-step reaction with 5 steps

1: 22 percent / 5M HCl / 12 h / 130 °C

2: thionyl chloride / tetrahydrofuran / 0.5 h / 0 °C

3: 76 percent / diethyl ether / 0 °C

4: 72 percent / butyl-lithium / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

5: 66 percent / lithium aluminium hydride / tetrahydrofuran / 0.5 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; In tetrahydrofuran; diethyl ether;