7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

Base Information

• Chemical Name: 7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one
• CAS No.: 115549-88-7
• Molecular Formula: C₁₆H₁₇N₅OS
• Molecular Weight: 327.41

Synonyms:7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

Chemical Property of 7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

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Technology Process of 7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

There total 2 articles about 7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (3939-01-3) + 5-amino-3-methylthio-1,2,4-triazole (45534-08-5) → 7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one (115549-88-7)

Guidance literature:

With polyphosphoric acid; at 80 ℃;

DOI:10.1007/s11172-012-0213-4

Reference yield: 29.0%

methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (3939-01-3) + 5-amino-3-methylthio-1,2,4-triazole (45534-08-5) → 7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one (115549-88-7) + 7-benzyl-2-methylthio-5,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-6(10H)-one (115549-89-8)

Guidance literature:

In acetic acid; for 5.5h; Heating;

Reference yield: 88.0%

7-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one (115549-88-7) + propynoic acid methyl ester (922-67-8) → methyl 7-benzyl-2-methylthio-11-oxo4,5,6,7,10,11-hexahydro[1,2,4]triazolo[1',5':1,2]pyrimido[4,5-d]azocine-9-carboxylate

Guidance literature:

In methanol; Reflux;

DOI:10.1007/s11172-012-0213-4

upstream raw materials:

methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

5-amino-3-methylthio-1,2,4-triazole

Downstream raw materials:

7-benzyl-2-methylthio-10-(2-piperidinoethyl)-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

7,10-dibenzyl-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

7-benzyl-10-(3-dimethylaminopropyl)-2-methylthio-6,7,8,9-tetrahydropyrido<4,3-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

7-benzyl-5-chloro-2-methylthio-6,7,8,9-tetrahydro[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine

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