1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Base Information

Chemical Name:1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole
CAS No.:950785-31-6
Molecular Formula:C₁₅H₁₄F₃N₃O₂
Molecular Weight:325.29
Hs Code.:

Synonyms:1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Suppliers and Price of 1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

There total 1 articles about 1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 100-14-1
4-nitrobenzyl chloride

: 890005-22-8,35179-55-6
3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

: 950785-31-6
1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 43.0%

: 950785-31-6
1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

: 4-{[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]methyl}aniline

Guidance literature:: 1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole; With sodium tetrahydroborate; palladium 10% on activated carbon; In methanol; water; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; water;

With sodium hydroxide; In methanol; water;

Reference yield:

: 950785-31-6
1-[(4-nitrophenyl)methyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

: 1-(4-{[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]methyl}phenyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / palladium 10% on activated carbon / methanol; water / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

2.2: 1 h

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; water;