(2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester

Base Information

• Chemical Name: (2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester
• CAS No.: 606148-95-2
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 606148-95-2.mol

Synonyms:(2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester

Chemical Property of (2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester

There total 3 articles about (2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethanol (64-17-5) + (2S)-2-benzyl-2-methylmalonamic acid ethyl ester (606148-94-1) → (2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester (606148-95-2)

Guidance literature:

With N-Bromosuccinimide; mercury(II) diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/S0957-4166(03)00456-7

Reference yield:

α-benzyl-α-methylmalononitrile (21455-96-9) → (2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester (606148-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Rhodococcus sp. CGMCC 0497 / 24 h / 30 °C / pH 7.0

2.1: H₂SO₄ / H₂O; ethanol / Heating

2.2: 98 percent / H₂O₂; NaOH / H₂O; ethanol / 3 h / 20 °C

3.1: 98 percent / Hg(OAc)2; N-bromosuccinimide / dimethylformamide / 16 h / 20 °C

With N-Bromosuccinimide; Rhodococcus sp. CGMCC 0497; sulfuric acid; mercury(II) diacetate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(03)00456-7

Reference yield:

(2S)-2-cyano-2-methyl-3-phenylpropanamide (28052-45-1) → (2R)-2-[(ethoxycarbonyl)amino]-2-methyl-3-phenylpropanoic acid ethyl ester (606148-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂SO₄ / H₂O; ethanol / Heating

1.2: 98 percent / H₂O₂; NaOH / H₂O; ethanol / 3 h / 20 °C

2.1: 98 percent / Hg(OAc)2; N-bromosuccinimide / dimethylformamide / 16 h / 20 °C

With N-Bromosuccinimide; sulfuric acid; mercury(II) diacetate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(03)00456-7

upstream raw materials:

ethanol

(2S)-2-benzyl-2-methylmalonamic acid ethyl ester

α-benzyl-α-methylmalononitrile

(2S)-2-cyano-2-methyl-3-phenylpropanamide

Downstream raw materials:

ethyl (R)-2-amino-2-methyl-3-phenylpropanoate