1(3H)-Isobenzofuranone,3-hydroxy-4-methyl-(9CI)

Base Information

Chemical Name:1(3H)-Isobenzofuranone,3-hydroxy-4-methyl-(9CI)
CAS No.:72288-75-6
Molecular Formula:C9H8 O3
Molecular Weight:164.16
Hs Code.:
Mol file:72288-75-6.mol

Synonyms:3-Hydroxy-4-methylisobenzofuran-1(3H)-one

Suppliers and Price of 1(3H)-Isobenzofuranone,3-hydroxy-4-methyl-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
3-hydroxy-4-methyl-1(3H)-Isobenzofuranone 97.00%
25G
$ 7320.00

AccelPharmtech
3-hydroxy-4-methyl-1(3H)-Isobenzofuranone 97.00%
5G
$ 3900.00

Total 3 raw suppliers

Chemical Property of 1(3H)-Isobenzofuranone,3-hydroxy-4-methyl-(9CI)

Chemical Property:

Melting Point:117.5-119.0 °C(Solv: benzene (71-43-2); hexane (110-54-3))
Boiling Point:389.1±42.0 °C(Predicted)
PKA:10.70±0.20(Predicted)
PSA：46.53000
Density:1.375±0.06 g/cm3(Predicted)
LogP:1.15630

Purity/Quality:

99% ^*data from raw suppliers

3-hydroxy-4-methyl-1(3H)-Isobenzofuranone 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1(3H)-Isobenzofuranone,3-hydroxy-4-methyl-(9CI)

There total 10 articles about 1(3H)-Isobenzofuranone,3-hydroxy-4-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1,1-diisopropyl-3-methoxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxasilole

: 72288-75-6
3-hydroxy-4-methylisobenzofuran-1(3H)-one

Guidance literature:: carbon dioxide; 1,1-diisopropyl-3-methoxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxasilole; With copper(l) iodide; cesium fluoride; In dimethyl sulfoxide; at 60 ℃; for 24h; Glovebox;

With hydrogenchloride; In water; dimethyl sulfoxide; at 0 ℃;
DOI:10.1039/c7gc00917h

Reference yield:

: 5448-36-2
3-methyl-N,N-diisopropylbenzamide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 72288-75-6
3-hydroxy-4-methylisobenzofuran-1(3H)-one

: 177166-16-4
3-hydroxy-6-methylisobenzofuran-1(3H)-one

Guidance literature:: 3-methyl-N,N-diisopropylbenzamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -50 - 20 ℃; Inert atmosphere;

With hydrogenchloride; acetic acid; In water; for 24h; Reflux; Inert atmosphere;
DOI:10.1021/ol203043h

Reference yield:

: 1711-06-4
3-Methylbenzoyl chloride

: 72288-75-6
3-hydroxy-4-methylisobenzofuran-1(3H)-one

: 177166-16-4
3-hydroxy-6-methylisobenzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / toluene / 24 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -50 - 20 °C / Inert atmosphere

2.3: 24 h / Reflux; Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/ol203043h