1(3H)-Isobenzofuranone,4-methyl-(9CI)

Base Information

• Chemical Name: 1(3H)-Isobenzofuranone,4-methyl-(9CI)
• CAS No.: 2211-83-8
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.161
• Hs Code.: 2932209090
• Mol file: 2211-83-8.mol

Synonyms:Phthalide,4-methyl- (7CI,8CI); 4-Methyl-1(3H)-isobenzofuranone; 4-Methylphthalide

Chemical Property of 1(3H)-Isobenzofuranone,4-methyl-(9CI)

Chemical Property:

• Vapor Pressure: 0.000113mmHg at 25°C
• Refractive Index: 1.574
• Boiling Point: 336.3°C at 760 mmHg
• Flash Point: 139.4°C
• PSA: 26.30000
• Density: 1.211g/cm³
• LogP: 1.66540

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-2-benzofuran-1(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1(3H)-Isobenzofuranone,4-methyl-(9CI)

There total 19 articles about 1(3H)-Isobenzofuranone,4-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

carbon dioxide (124-38-9,18923-20-1) + 1,1-diisopropyl-4-methyl-1,3-dihydrobenzo[c][1,2]oxasilole → 4-methyl-3H-isobenzofuran-1-one (2211-83-8)

Guidance literature:

carbon dioxide; 1,1-diisopropyl-4-methyl-1,3-dihydrobenzo[c][1,2]oxasilole; With copper(l) iodide; cesium fluoride; In dimethyl sulfoxide; at 60 ℃; for 24h; Glovebox;

With hydrogenchloride; In water; dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.1039/c7gc00917h

Reference yield: 74.0%

1-oxo-1,3-dihydroisobenzofuran-4-yl trifluoromethanesulfonate + methylmagnesium bromide (75-16-1) → 4-methyl-3H-isobenzofuran-1-one (2211-83-8)

Guidance literature:

With iron(III)-acetylacetonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 0 ℃; for 0.5h;

DOI:10.1002/ejoc.201300102

Reference yield: 72.0%

6-Oxo-6H-pyran-2-carboxylic acid (E)-but-2-enyl ester (98369-31-4) → 4-methyl-3H-isobenzofuran-1-one (2211-83-8)

Guidance literature:

palladium on activated charcoal; In 1,2-dichloro-benzene; for 36h; Heating;

upstream raw materials:

3-methylphthalic acid anhydride

6-Oxo-6H-pyran-2-carboxylic acid (E)-but-2-enyl ester

2,3-dimethylbenzoyl chloride

4-Bromomethyl-3H-isobenzofuran-1-one

Downstream raw materials:

3-hydroxy-4-methylisobenzofuran-1(3H)-one

1-oxo-1,3-dihydro-isobenzofuran-4-carbaldehyde