5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile

Base Information

Chemical Name:5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile
CAS No.:1232068-57-3
Molecular Formula:C₂₁H₁₃ClFN₃O₂S
Molecular Weight:425.871
Hs Code.:

Synonyms:5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile

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Chemical Property of 5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile

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Technology Process of 5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile

There total 6 articles about 5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 214210-21-6
3-cyano-4-fluorophenylboronic acid

: 1232069-08-7
1-{[5-Bromo-4-(3-chlorophenyl)thiophen-2-yl]carbonyl}imidazolidin-4-one

: 1232068-57-3
5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In monoethylene glycol diethyl ether; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 62224-17-3
4-bromothiophene-2-carboxylic acid ethyl ester

: 1232068-57-3
5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 1.5 h / 80 °C / Inert atmosphere

2: bromine; acetic acid / 24 h / 60 °C

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

5: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; bromine; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; monoethylene glycol diethyl ether; water;

Reference yield:

: 16694-18-1
4-bromo-thiophene-2-carboxylic acid

: 1232068-57-3
5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / Reflux

1.2: 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 1.5 h / 80 °C / Inert atmosphere

3.1: bromine; acetic acid / 24 h / 60 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

6.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; bromine; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; monoethylene glycol diethyl ether; water;