N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide

Base Information

Chemical Name:N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide
CAS No.:923971-28-2
Molecular Formula:C₁₈H₂₃N₅O₅
Molecular Weight:389.411
Hs Code.:

Synonyms:N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide

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Chemical Property of N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide

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Technology Process of N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide

There total 4 articles about N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 923971-26-0
(+/-)-N-(7-acetyl-6-hydroxy-4-oxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)acetamide

: 102-56-7,102526-87-4
2,5-dimethoxyaniline

: 923971-28-2
N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide

Guidance literature:: With trimethylamine borane; acetic acid; In methanol; at 20 ℃; for 12h;
DOI:10.1002/jhet.5570430615

Reference yield:

: 52133-67-2
ethyl 2-cyano-4,4-diethoxybutyrate

: 923971-28-2
N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methoxide / ethanol / 2.5 h / 95 °C

1.2: 17 percent / ethanol / 12 h / 20 °C

2.1: pyridine / 5 h / 90 °C

2.2: 59 percent / pyridine / 12 h / 20 °C

3.1: 32 percent / H₂O / 144 h / 20 °C

4.1: 9 percent / borane trimethylamine; acetic acid / methanol / 12 h / 20 °C

With sodium methylate; trimethylamine borane; acetic acid; In pyridine; methanol; ethanol; water;
DOI:10.1002/jhet.5570430615

Reference yield:

: 63026-85-7
2,6-diamino-5-(3,3-diethoxyethyl)pyrimidin-4(3H)-one

: 923971-28-2
N-{4-acetylamino-5-[2-(2,5-dimethoxyphenylamino)ethyl]-6-oxo-1,6-dihydro-pyrimidin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 5 h / 90 °C

1.2: 59 percent / pyridine / 12 h / 20 °C

2.1: 32 percent / H₂O / 144 h / 20 °C

3.1: 9 percent / borane trimethylamine; acetic acid / methanol / 12 h / 20 °C

With trimethylamine borane; acetic acid; In pyridine; methanol; water;
DOI:10.1002/jhet.5570430615