Technology Process of (1R,2S)-2-(4-hydroxy-3-methoxyphenyl)cyclohex-3-enecarbaldehyde
There total 4 articles about (1R,2S)-2-(4-hydroxy-3-methoxyphenyl)cyclohex-3-enecarbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
hexane; dichloromethane;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.1080/00397911.2013.846380
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / toluene / 1 h / Reflux
2: titanium tetrachloride / dichloromethane / 2 h / -20 °C
3: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 °C / Inert atmosphere
With
titanium tetrachloride; diisobutylaluminium hydride; toluene-4-sulfonic acid;
In
hexane; dichloromethane; toluene;
2: |Diels-Alder Cycloaddition;
DOI:10.1080/00397911.2013.846380
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium chloride; zinc / tetrahydrofuran; water / 0.5 h / 0 °C
2: toluene-4-sulfonic acid / toluene / 1 h / Reflux
3: titanium tetrachloride / dichloromethane / 2 h / -20 °C
4: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 °C / Inert atmosphere
With
titanium tetrachloride; diisobutylaluminium hydride; ammonium chloride; toluene-4-sulfonic acid; zinc;
In
tetrahydrofuran; hexane; dichloromethane; water; toluene;
3: |Diels-Alder Cycloaddition;
DOI:10.1080/00397911.2013.846380
