2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Base Information

Chemical Name:2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol
CAS No.:1450620-78-6
Molecular Formula:C₂₁H₂₃F₃N₄O₄S
Molecular Weight:484.499
Hs Code.:

Synonyms:2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

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Chemical Property of 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

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Technology Process of 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

There total 19 articles about 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-77-5
benzyl (3S)-4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1450620-78-6
2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Guidance literature:: benzyl (3S)-4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate; With trifluorormethanesulfonic acid; trifluoroacetic acid; for 1h;

tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1572928-03-0
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1450620-78-6
2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm5000497

Reference yield:

: 4214-76-0,67476-67-9
5-nitro-pyridin-2-ylamine

: 1450620-78-6
2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; dmap / dichloromethane / 18 h / 20 °C

2.1: ammonium chloride; zinc / water; methanol; tetrahydrofuran / 12 h / 20 °C

3.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 0.5 h / 0 °C

3.2: 0.75 h / 0 °C

4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / 1 h

4.2: 1 h / 20 °C

With hydrogenchloride; dmap; trifluorormethanesulfonic acid; ammonium chloride; triethylamine; trifluoroacetic acid; zinc; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;