(R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine

Base Information

• Chemical Name: (R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine
• CAS No.: 288305-89-5
• Molecular Formula: C₁₇H₂₂N₆O
• Molecular Weight: 326.401
• Mol file: 288305-89-5.mol

Synonyms:(R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine

Chemical Property of (R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine

There total 3 articles about (R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(2R)-2-aminobutan-1-ol (5856-63-3) + 2-chloro-6-benzylamino-9-methylpurine (101622-53-1) → (R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine (288305-89-5)

Guidance literature:

at 170 ℃; for 11h;

DOI:10.1021/ml3002083

Reference yield:

2,6-dichloro-9-methyl-9H-purine (2382-10-7) → (R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine (288305-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / butan-1-ol / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2: 11 h / 170 °C

With triethylamine; In butan-1-ol;

DOI:10.1021/ml3002083

Reference yield:

2,6 dichloropurine (5451-40-1) → (R)-6-(benzylamino)-2-[[(1-hydroxymethyl)propyl]amino]-9-methylpurine (288305-89-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 0 °C

2: triethylamine / butan-1-ol / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

3: 11 h / 170 °C

With potassium carbonate; triethylamine; In N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1021/ml3002083

upstream raw materials:

(2R)-2-aminobutan-1-ol

2-chloro-6-benzylamino-9-methylpurine

2,6 dichloropurine

2,6-dichloro-9-methyl-9H-purine