(S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

Base Information

Chemical Name:(S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride
CAS No.:99198-16-0
Molecular Formula:C₂₅H₃₄N₂O₈*ClH
Molecular Weight:527.014
Hs Code.:

(S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

Synonyms:(S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

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Chemical Property of (S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

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Technology Process of (S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

There total 15 articles about (S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 99228-15-6
(S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester

: 99198-16-0
(S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 6048-09-5
3-cyclohexylacrylic acid ethyl ester

: 99198-16-0
(S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / H₂ / 10 percent Pd-C / ethanol / Ambient temperature

2: 1) NaOEt; 2) H₂SO₄, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

3: 20 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 85 percent / 1 N NaOH / H₂O / 2 h / Ambient temperature

5: 88 percent / NaHCO₃ / dimethylformamide / Ambient temperature

6: 94 percent / 5 N HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; sodium hydrogencarbonate; sodium chloride; palladium on activated charcoal; In ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 99197-80-5
(S)-tert-butyl (4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepine-3-yl)aminoformate

: 99198-16-0
(S)-2-((S)-9-Carboxymethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid ethoxycarbonylmethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / 5 N HCl / ethyl acetate / 3 h / Ambient temperature

2: 92 percent / K₂CO₃ / ethyl acetate; H₂O / 1 h / 0 °C

3: 96 percent / K₂CO₃, KI / dimethylformamide / Ambient temperature

4: 67 percent / H₂ / 5 percent Pd-C / methanol / Ambient temperature

5: 20 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

6: 85 percent / 1 N NaOH / H₂O / 2 h / Ambient temperature

7: 88 percent / NaHCO₃ / dimethylformamide / Ambient temperature

8: 94 percent / 5 N HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4 A molecular sieve; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128