1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

Base Information

• Chemical Name: 1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil
• CAS No.: 847605-67-8
• Molecular Formula: C₂₄H₂₉N₃O₉Si
• Molecular Weight: 531.594

Synonyms:1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

Chemical Property of 1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

There total 3 articles about 1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil (847605-66-7) → 1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil (847605-67-8)

Guidance literature:

With water; trifluoroacetic acid; at 80 ℃; for 12h;

DOI:10.1002/hlca.200490271

Reference yield:

2-nitrobenzyl chloride (610-14-0) → 1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil (847605-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 4-(dimethylamino)pyridine / pyridine; CH₂Cl₂ / 60 h / 23 °C

2: 100 percent / CF₃COOH; H₂O / 12 h / 80 °C

With dmap; water; trifluoroacetic acid; In pyridine; dichloromethane;

DOI:10.1002/hlca.200490271

Reference yield:

1-[6,7-dideoxy-2,3-O-isopropylidene-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil (292636-93-2) → 1-[6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil (847605-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 4-(dimethylamino)pyridine / pyridine; CH₂Cl₂ / 60 h / 23 °C

2: 100 percent / CF₃COOH; H₂O / 12 h / 80 °C

With dmap; water; trifluoroacetic acid; In pyridine; dichloromethane;

DOI:10.1002/hlca.200490271

upstream raw materials:

1-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

2-nitrobenzyl chloride

1-[6,7-dideoxy-2,3-O-isopropylidene-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

Downstream raw materials:

3-benzoyl-1-[2,3-di-O-benzoyl-6,7-dideoxy-5-O-(2-nitrobenzoyl)-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

1-[6,7-dideoxy-5-O-(4,4'-dimethoxytrityl)-7-C-(triethylsilyl)-2-O-{[(triisopropylsilyl)oxy]methyl}-α-L-talo-hept-6-ynofuranosyl]uracil

3-benzoyl-1-[2,3-di-O-benzoyl-6,7-dideoxy-7-C-(triethylsilyl)-α-L-talo-hept-6-ynofuranosyl]uracil

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