3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

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Chemical Name:3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester
CAS No.:389868-11-5
Molecular Formula:C₆₃H₇₇NO₁₇
Molecular Weight:1120.3
Hs Code.:

3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

Synonyms:3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

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Chemical Property of 3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

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Technology Process of 3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

There total 5 articles about 3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 187404-16-6
benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate

: 389868-07-9
(2S,3S,4R)-4-((2R,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid (3,4-dimethoxy-phenyl)-amide

: 389868-11-5
3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

Guidance literature:: (2S,3S,4R)-4-((2R,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-carboxylic acid (3,4-dimethoxy-phenyl)-amide; With di(n-butyl)tin oxide; In methanol; Heating;

benzyl (R)-3-cyclohexyl-2-trifluoromethanesulfonyloxy-propionate; With cesium fluoride; In 1,2-dimethoxyethane;
DOI:10.1002/1521-3773(20011001)40:19<3644::AID-ANIE3644>3.0.CO;2-S

Reference yield:

: 6315-89-5
3,4-dimethoxyaniline

: 389868-11-5
3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / HBTU; Et₃N / dimethylformamide

2.1: 98 percent / NaOMe / methanol

3.1: Bu₂SnO / methanol / Heating

3.2: 31 percent / CsF / 1,2-dimethoxy-ethane

With sodium methylate; di(n-butyl)tin oxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/1521-3773(20011001)40:19<3644::AID-ANIE3644>3.0.CO;2-S

Reference yield:

: 389868-03-5
C₆₇H₆₆O₁₇

: 389868-11-5
3-cyclohexyl-2-{2-[2-(3,4-dimethoxy-phenylcarbamoyl)-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: (ClCO)2; DMSO / CH₂Cl₂ / -60 °C

1.2: 78 percent / NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol

2.1: 80 percent / HBTU; Et₃N / dimethylformamide

3.1: 98 percent / NaOMe / methanol

4.1: Bu₂SnO / methanol / Heating

4.2: 31 percent / CsF / 1,2-dimethoxy-ethane

With oxalyl dichloride; sodium methylate; di(n-butyl)tin oxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1521-3773(20011001)40:19<3644::AID-ANIE3644>3.0.CO;2-S