(24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate

Base Information

• Chemical Name: (24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate
• CAS No.: 268540-27-8
• Molecular Formula: C₃₆H₅₃BrO₄
• Molecular Weight: 629.718
• Mol file: 268540-27-8.mol

Synonyms:(24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate

Chemical Property of (24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate

There total 3 articles about (24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(24R)-3β,5-dihydroxy-5α-stigmastan-6-one 3-benzoate (268540-26-7) → (24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate (268540-27-8)

Guidance literature:

With bromine; In acetic acid; at 60 - 70 ℃; for 1h;

DOI:10.1007/BF02282512

Reference yield:

(24R)-3β,5α-dihydroxy-24-ethyl-5α-cholestan-6-one (55051-78-0) → (24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate (268540-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / pyridine / 21 h / 20 °C

2: 92 percent / Br₂ / acetic acid / 1 h / 60 - 70 °C

With bromine; In pyridine; acetic acid; 1: Acylation / 2: Bromination;

DOI:10.1007/BF02282512

Reference yield:

benzoyl chloride (98-88-4) → (24R)-3β,5-dihydroxy-7α-bromo-5α-stigmastan-6-one 3-benzoate (268540-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / pyridine / 21 h / 20 °C

2: 92 percent / Br₂ / acetic acid / 1 h / 60 - 70 °C

With bromine; In pyridine; acetic acid; 1: Acylation / 2: Bromination;

DOI:10.1007/BF02282512

upstream raw materials:

(24R)-3β,5-dihydroxy-5α-stigmastan-6-one 3-benzoate

(24R)-3β,5α-dihydroxy-24-ethyl-5α-cholestan-6-one

benzoyl chloride

Downstream raw materials:

(24R)-3β,5-dihydroxy-5α-stigmast-7-en-6-one 3-benzoate