5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

Base Information

Chemical Name:5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine
CAS No.:1256466-50-8
Molecular Formula:C₃₇H₄₇N₃O₆SeSi
Molecular Weight:736.842
Hs Code.:

Synonyms:5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

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Technology Process of 5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

There total 1 articles about 5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1256466-51-9
5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxyuridine

: 1256466-50-8
5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: 5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxyuridine; With tri-isopropylbenzenesulfonyl chloride; dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; for 16h;

With sodium hydroxide; In acetonitrile; at 20 ℃; for 1h;

Reference yield: 84.0%

: 1256466-50-8
5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

: 98-88-4
benzoyl chloride

: 1256466-52-0
4-N-benzoyl-5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: In pyridine; for 1h;

Reference yield:

: 1256466-50-8
5-methylseleno-3'-tert-butyldimethylsilyl-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

: 1256466-53-1
4-N-benzoyl-5-methylseleno-5'-O-(4',4''-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C

2: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / pH 7 / Inert atmosphere; Cooling with ice

With pyridine; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1002/asia.201100898